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Concentric hypertrophy following pressure-overload is linked to preserved systolic function but impaired diastolic function, and is an important substrate for heart failure with preserved ejection fraction. The ability to generate patient-specific induced pluripotent stem cells (iPSCs) provides a unique opportunity for modeling heart disease in vitro. Er leitete von 1977 bis 2014 das Institut für Humangenetik der Medizinischen Fakultät der Universität Göttingen. With this reproductive behaviour, breeding methods appropriate for faba bean should be general solutions of which the methods for self-fertilizing and cross-fertilizing crops should be just extreme, marginal cases. November 1940 in Ludwigshafen; † 7. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. Dort erfahren Sie auch die vollständige Adresse von Link Wolfgang Dr. in Göttingen-Groß Ellershausen, um Post dorthin zu schicken. nat., University of Göttingen. Rudolf-Schwander-Str. Mesenchymal stromal cells (MSC) have cardiac-protective properties. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. Male New Zealand White rabbits were injected intravenously with DOXO twice weekly for 8 wk [DOXO... Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Ahmed Sallam, 2014: Detailed genetic approach to improve frost tolerance of German winter faba beans. Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. Supplementary Figure Set for Unger et al., Acta Neuropathol Commun. Languages. Tel. With the MICOS complex, OPA1 and the F 1 F o -ATP synthase, key players of cristae bio … A CARDIAC α-ACTIN (ACTC1) GENE MUTATION CAUSES ATRIAL-SEPTAL DEFECTS ASSOCIATED WITH DILATED CARDIOMYOPATHY, A HaloTag-TEV genetic cassette for mechanical phenotyping of native proteins, Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload, A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart, SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy, Specific Cleavage of the Titin Springs In Situ Uncovers the Role of Titin-Based Force in Sarcomere Structure and Muscle Contraction, Treatments targeting inotropy: A position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European Society of Cardiology Heart failure/cardiomyopathy, Early myocardial changes induced by doxorubicin in the non-failing dilated ventricle, Titin as a force generating muscle protein under regulatory control. Loop is the open research network that increases the discoverability and impact of researchers and their work. Methods: Göttingen. 234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017. Recent reports suggest that mammalian embryonic coronary endothelium (CoE) develops from the sinus venosus and ventricular endocardium. However, testing these mechanical hypotheses on native molecules in their natural environment remains inaccessible to conventional genetics, biophysics and molecular biology tools. Dort liegen die Eiweiße Myosin und Aktin als Myofilamente vor. entropic effect of the massive native titin polypeptide is lost. Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Accordingly, regulated protein decay is critical to maintain cardiac function. Here, we characterise the molecular stru... Background We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein mi... Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. International space missions with ESA and NASA. Research Institution in Göttingen, Germany. Kontakt: Telefon: 0551/400-4561 Telefax: 0551/400-4580 E-Mail: w.steinmetzer@goettingen.de Raum: 110 ZUR ÜBERSICHT. This reasoning serves as entrance into our faba bean breeding research, an area that offers numerous challenges and promises due to the bean being a legume (pulse) crop, due to its seed being food and feed in temperate and semi-arid zones, due to it being a field and a garden crop and because winter and spring types exist. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. Cuvillier Göttingen (in Zusammenarbeit mit. While increased passive stiffness of the myocardium is a suggested mechanism underlying diastolic dysfunction in these hearts, the contr... Reversible post-translational modifications of various cardiac proteins regulate the mechanical properties of the cardiomyocytes and thus modulate the contractile performance of the heart. Leben. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. Methods: Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the de... Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). We explored whether intravenous (i.v.) We therefore investigated the influence of CX3CR1 ablation in the mode... Regulation of chemokine receptors and the corresponding chemokines in the spleen of Coxsackievirus B3-infected mice. Die Telefonnummer 0551 9 48 00 finden Sie ganz oben auf der Seite. Research focus on the solar system with its planets and moons, comets and asteroids, and of course the Sun. Im Wintersemester 1921/22 wurde Pauli planmässiger Assistent von Professor Max Born (Link verlässt diese Seite).Born kehrte in diesem Jahr an seine Alma Mater zurück, an der er sich bereits 1909 habilitiert hatte. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. Die 25-jährige Studentin engagiert sich in der Gruppierung Basisdemokratische Linke in Göttingen, wo der Schock tief sitzt. Kontakte Fraktion Göttinger Linke . 930/931 (9.Stock) Hiroshimaplatz 1-4 37083 Göttingen Telefon 05 51-4 00 23 47 in Europe; GIE féverole, Fachgespräch „Körnerleguminosen in Deutschland“ 2009 JKI Braunschweig, Markergestützte Selektion der optimalen DH-Linie, Link and Ghaouti 2012 Organic faba bean breeding, Genes count, pyramiding alleles, Summer Seminar 2014, Schnell Zweisatz-Gitter-Anlage Versuchsanlage, 1999 Geiger Populationsgenetik + Pflanzenzüchtung, Directories of courses and people (UniVZ), DFG Projekt: "Molecular and quantitative-genetic analysis of seed size in faba bean (, Abo-Vici: "Breeding and agronomy of novel, low-vicine faba beans and adoption as domestic protein feed", Faba bean: Genetic analysis of the Ascochyta-resistance of faba bean (, Faba bean: genetic increase and stabilization of grain yield via optimum exploitation of heterosis; Analysis of pollination and pollinators, Breeding research on the mixed cropping of faba bean and wheat, Regional chicken races, regional protein feed ("PorReE"), Population structure und breeding method in case of partial allogamy, Research on faba bean drought and weed tolerance in Morocco. The endothelial glycocalyx, a carbohydrate-rich layer lining the endothelial luminal surface, is a first line defense against... Background: Bar graphs represent the mean ± SEM of splenic (A) CCR2, (B) MCP-1, (C) CX3CR1, and (D) CX3CL1 gene expression, as indicated, after normalization to the housekeeping gene 18S using the 2−ΔCt formula and normalized to the WT group, wh... Heterozygous variants in BICD cargo adapter 2 (BICD2) cause autosomal dominant spinal muscular atrophy, lower extremity-predominant 2 (SMALED2). To date, the role of this interaction in the stress response of muscle remains poorly understood. Due to our privacy policy, only current members can send messages to people on ResearchGate. Imbalances in protein homeostasis caused by mutant desmin, 234th ENMC International Workshop: Chaperone dysfunction in muscle disease, December 8-10th 2017, Naarden, Netherlands, A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance. English, German. 96 Einträge zu Wolfgang Link mit aktuellen Kontaktdaten, Öffnungszeiten und Bewertungen ☎ Das Telefonbuch - Ihre Nr. The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. Its mission is to provide high-quality human heart tissue for research into the molecular basis of human heart failure by working collaboratively with experts in this field. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. The spring region of the giant muscle protein titin contains many immunoglobulin-like (Ig) domains, which unfold and refold under low (physiological) stretch forces. nach Vereinbarung. Es gibt 30+ Personen namens „Wolfgang Link“, die LinkedIn zum Austausch von Informationen, Ideen und Karrierechancen nutzen. Current projects: Public relations activity at Reinshof Cuvillier Verlag Göttingen. Crucial role of protein kinase G in regulating Ca2(+)/calmodulin-dependent protein kinase-II activity and oxidative stress: The diastolic function modulation via PKG-dependent CaMKII phosphorylation and oxidation. Various professional articles, publications and lectures on general corporate law related issues as well as capital markets subjects. To expand the spectrum of bicaudal D, Drosophila, homologue 2 (BICD2) gene-related diseases, which so far includes autosomal dominant spinal muscular atrophy with lower extremity predominance 2 and hereditary spastic paraplegia due to mutations in the BICD2 gene. Gregor Welna, 2014: Genetische Analysen für eine markergestützte Verbesserung der Trockenstresstoleranz von Winterackerbohnen. E-Mail: neurologie.sekretariat(at)med.uni … Aging is associated with an increased risk of cardiovascular disease and death. Sorry, you need to be a researcher to join ResearchGate. TTNtv are also encountered in [sim]1% of the general population, where they may be silent, perhaps reflecting allelic factors. We combined a geno... Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Daniel Siebrecht-Schöll, 2019: Breeding analysis of eight winter faba bean genotypes for mixed cropping with winter wheat. The elasticity of muscle is principally determined by the I-band region of titin, consisting of 40-100 immunoglobulin-like (Ig) domains and The giant sarcomere protein titin is important in both heart health and disease. 34117 Kassel . Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy, Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes, The Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme, Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin, A Multi-Tool Mouse Model to Study the Elasticity of Native Titin, Dietary spermidine for lowering high blood pressure, Titin-truncating variants affect heart function in disease cohorts and the general population, Cardioprotection and lifespan extension by the natural polyamine spermidine, Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement, Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection FractionClinical Perspective, Developmental Basis of Cardiac Inherited Diseases470Extracardiac endothelium patterns embryonic coronary arterio-venous connections471DCM-associated RBM20-mutations lead to aberrant splicing of titin and ryanodin receptor 2 in the human myocardium472The impact of missense versus nonsense mutations in arrhythmogenic cardiomyopathy phenotype, Expression and function of dipeptidyl peptidases. We hypothesized that angiopoietin-2 (Angpt-2), antagonist of the endothelium-stabilizing receptor Tie2, induces a rapid loss of the eGC in human sepsis. Cooperation with IAV Hassan II (, Reproductive features and vicine content of faba bean (, Drought tolerance, marker application, faba bean (, Awadallah Abdalla Abdelmula, 1999: Genetic improvement of drought tolerance in faba beans, Hilke M. Riemer, 1999: Nmin nach Ernte: Genotypische Variation in aktiuellem Material von Ackerbohnen (, Jens Christian Vaupel, 1999: Neue CMS-Systeme für die Produktion von Minor x Major-Hybridsorten bei, Memen Surahman, 2001: Detailed genetic analysis of a wide faba bean (, Anja Kramer, 2002: Untersuchungen zum biotechnologisch unterstützten Gentransfer bei der Ackerbohne, Andi Wijaya, 2003: Towards interspecific hybridization in, Mahmoud Mohamed Zeid, 2003: Analysis of genetic diversity based on molecular markers (AFLP) and of heterosis in faba bean (. application of PLacenta-eXpanded (PLX) MSC-like cells (PLX) improves LV diastolic relaxation in streptozotocin (STZ)-induced diabetic mice and i... Myopathies encompass a wide variety of acquired and hereditary disorders. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. 207 likes. Wolfgang. The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. Here, we report a large, multi-generational family (78 members) with ASD combined with a late-onset dilated cardiomyopathy and further characterize the consequences of mutant α-actin. Diese Bewegungen werden durch spezielle Struktur- und Motorproteine in den Muskelzellen ermöglicht. Aims A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Breeding Research Nursery Desmin is the major intermediate filament (IF) protein in human heart and skeletal muscle. We analyzed 2 independent German families with clinical, geneti... Background: Bei Vielzellern sind die Skelettmuskeln für die Fortbewegung zuständig. Universität Göttingen. Descriptive terms such as 'HFrEF' (... Titin is a giant elastic protein expressed in the contractile units of striated muscle cells, including the sarcomeres of cardiomyocytes. We investigated newly generated immortalized heterozygous and homozygous R349P desmin knock‐in myoblasts in conjunction with the corresponding desminopathy mice as models for desminopathies to analyse major protein quality control processes in response to the presence of R349P mutant desmin. Although several studies in non-mammalian vertebrates have proven that extracardiac endothelial cells also participate in CoE development, the contribution of such cells to mammalian CoE is regarded to be minor and... Elucidating the biological mechanisms behind increased myocardial compliance following acute myocardial stretching and their role in cardiac diastolic (dys)function. Voges, 2007: Genetische Analyse von Heterosis im jüngsten Stadium einer Pflanze, als Embryo, am Beispiel der Fababohne (, Franziska Roth, 2010: Evaluierung von Winterackerbohnen als Zwischenfrucht für eine ökologische Biogasproduktion. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may progress to heart failure. Familial atrial septal defect (ASD) has previously been attributed primarily to mutations in cardiac transcription factors. We argue that, by comparing tissues from failing human hearts with age-matched non-fail... Studies on inflammatory disorders elucidated the pivotal role of the CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases progression. Methods Reminiscent of Myo18b, Myo18a was highly exp... Cardiac functionality is dependent on a balanced protein turnover. • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow, low-gradient AS with preserved ejection fraction. Wolfgang Rode Innenarchitekt in Göttingen im Branchenbuch von meinestadt.de - Telefonnummer, Adresse, Stadtplan, Routenplaner und mehr für Wolfgang Rode Innenarchitekt Göttingen The giant protein titin forms a continuous filament network in the sarcomeres of striated muscle cells, where it determines passive tension development and modul... Membrane deformation by proteins is a universal phenomenon that has been studied extensively in eukaryotes but much less in prokaryotes. Briefpostadresse 37099 Göttingen . So far, only a limited number of DES pathogenic variants have been identified... A detailed description of pathophysiological effects that viruses exert on their host is still challenging. All rights reserved. agric. Wolfgang Wucherpfennig ist Bürgermeister der Samtgemeinde Radolfshausen.Er wurde am 12. Rationale: Jedoch findet man molekulare Bewegungsvorgänge in allen Zelltypen. We show extensive translational control of cardiac gene expression, which i... Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations with high risk to enhance statistical power. Dezember 2015 in Lenglern) war ein deutscher Arzt und Hochschullehrer. © 2008-2021 ResearchGate GmbH. Sehen Sie sich das Profil von Wolfgang Link im größten Business-Netzwerk der Welt an. Left atrial (LA) compliance and contractility influence left ventricular stroke volume. Join ResearchGate to contact this researcher and connect with your scientific community. The correct name should be W. A. Linke, which is shown correctly in the authorgroup section above. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify how titin-based forces define myocyte ultrastructure and mechanics. Rathaus. We generated a zebrafish model of an A-band TTNtv identified in 2... BACKGROUND:Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Join ResearchGate to find the people and research you need to help your work. Finde 12 Profile von Wolfgang Link mit aktuellen Kontaktdaten ☎, Lebenslauf, Interessen sowie weiteren beruflichen Informationen bei XING. ll Wolfgang Link gesucht? Der Seulinger ist seit fast acht Jahren hauptamtlicher Bürgermeister, politisch engagiert er sich aber schon wesentlich länger: Vor 30 Jahren trat er in die SPD ein und wurde schnell in den Seulinger Gemeinderat gewählt. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Objective: 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Erstes Album [wolf:gang] 25.08.18 SP... Alle tierischen Lebewesen, selbst Einzeller, bewegen sich fort. MPS develops and builds scientific instruments that investigate solar system bodies. Wolfgang A. Linke Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. 205 likes. Research Assistant, Mathematical Institute, University of Göttingen. In this study, we discovered a membrane-deforming activity of the phospholipid N -methyltransferase PmtA from the plant-pathogenic bacterium Agrobacterium tumefaciens . Stadt Göttingen Breslauer Straße 2 37085 Göttingen. Winda Puspitasari, 2017: Association analyses to genetically study reproduction and seed quality features of faba bean (. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD ⁺ ). Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). Universitätsmedizin Göttingen Klinik für Neurologie Robert-Koch-Straße 40 37075 Göttingen . Posttranslational modifications of titin from cardiac muscle: how, where and what for? Methods Participation in “Cells in Motion” Research interests: muscle cytoskeletal dynamics, biomolecular and cellular force measurements, atomic force microscopy, cardiomyocyte contractility and elasticity in health and disease, induced pluripotent stem cell-derived cardiomyocytes Papers in the research focus “cell dynamics and imaging” papers by Wolfgang A. Linke Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. This file is licensed under the Creative Commons Attribution 3.0 Unported license. März 1949 geboren. Indeed, there is a tight link in terms of shared risk factors and mechanisms... AimsOur aim was to investigate the effect of nitric oxide (NO)-independent activation of soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model with diastolic dysfunction and in biopsies from human heart failure with preserved ejection fraction (HFpEF).Methods Professor Dr. Wolfgang Link, Abteilung Zuchtmethodik der Pflanze, Carl-Sprengel-Weg 1, 37075 Göttingen This review summarizes recent insight into the mechanisms behind how titin gene mutations cause hereditary cardiomyopathy and how titin prot... Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Die Universitätsmedizin Göttingen (UMG) ist Ihr Ansprechpartner für medizinische Versorgung, Lehre und Forschung auf höchstem Niveau. 1 für Adressen und Telefonnummern Small heat shock proteins such as alphaB-crystallin (aBC) translocate under physiological or pathological stress to the titin springs. Wolfgang. Aims: More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. So-called ‘desminopathies’ are disorders due to pathogenic variants in the DES gene and are associated with skeletal myopathies and/or various types of cardiomyopathies. Sehen Sie sich die Profile von Fach- und Führungskräften namens „Wolfgang Link“ auf LinkedIn an. Sie werden durch elastische Titinfilamente zusammengehalten. He has written four works of comparative literature and psychology of art, now considered standards of their genre. A personal tribute to Johann Caspar Rüegg (1930–2018): milestones of muscle research, JACBTS Gotzmann Linke Published SupplFigure, Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis, Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1, Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo, P497Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbidities, Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening, Stretch-induced compliance: A novel adaptive biological mechanism following acute cardiac load, Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease, Genetically Engineered Human Stem-Cell Derived Cardiomyocytes to Investigate the Function of Cronos Titin, Quantifying the Titin Contribution to Muscle Force Generation using a Novel Method to Specifically Cleave the Titin Springs in Situ, Supplementary Figures&Table Nat-Commun Revision Final corrected, Titin Truncation Position Determines Propensity for Dilated Cardiomyopathy, Impaired Ventricular Relaxation and Passive Stiffness in Zebrafish, Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Placenta-Derived Adherent Stromal Cells Improve Diabetes Mellitus-Associated Left Ventricular Diastolic Performance: Placenta Stromal Cells and Diastolic Relaxation, Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function, Supplementary Figure S1 for Unger et al., Acta Neuropathol Commun.

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